The CAAM research and development lab is located at Sermolab S.r.l. There the experimental procedures are developed and tests are performed on new allergens and new diagnostic systems. All clinical activities performed in the CAAM healthcare network are addressed to the production of scientific data, to acquire new knowledge to be transferred in the routine care as quickly as possible.
Our main research interests are summarized below:
The CAAM has developed and maintained over the time stable partnerships with major research and development centers in Italy and abroad. In details with:
Institute of Bioscience and Bioresources, Consiglio Nazionale delle Ricerche, Naples, Italy.
The research laboratory is directed by Professor Maria Antonietta Ciardiello. It is one of the reference laboratories in Italy for the study on proteins.
In the laboratory all activities for protein extract preparations from tissues of various allergen sources are performed, as well as the identification and characterization of allergenic proteins including their sequencing, preparing them for subsequent use in diagnostics and for applications in the CAAM research laboratory.
The CAAM researchers are in close contact with leading researchers in the laboratory. Dr. Maurizio Tamburrini, Dr.ssa Lisa Tuppo, and Dr.ssa Ivana Giangrieco, work full-time on research and developments in the field of allergy.
IBBR-CNR is a Platinum Project Partner of the Allergome platform along with ADL, MacroarrayDx, IFARAI and CAAM.
IBBR-CNR is developing partner of the FABER diagnostic test for IgE detection in allergic diseases. In the IBBR-CNR lab exclusive allergenic molecules and verified allergenic extracts are produced, and the quality of materials obtained by other manufacturers is verified.
Christian Harwanegg , one of the inventors of the first allergy test in microtechnology, the ISAC test, created MacroarrayDx in 2015. The idea is to generate new diagnostic systems upgrading the first generation microtechnology using the available nanotechnologies. Taking advantage of his huge expertise in the field, more than 15 years spent in bringing ISAC test from the 2002 experimental version to the current routine test, Dr. Harwanegg is now collaborating with CAAM and its partners and together they have released the FABER IgE allergy test.
In the FABER test development, MacroarrayDx is taking advantage of the collaboration and of the great technical expertise of Georg Mitterer, who has worked for 10 years to bring the ISAC test at its best performances, and now is fully engaged on the FABER development.
MacroarrayDx is a Platinum Project Partner of the Allergome platform along with IBBR-CNR, ADL, IFARAI and CAAM.
CAAM maintains a privileged cooperation with the Allergy Data Laboratories s.c. (ADL), the company that has created and developed the Allergome website, maintaining it since 2003.
Beyond the Allergome platform, ADL has developed the most important operational tool for the CAAM: the electronic medical record InterAll. This is the only example of a structured database for allergy specialists, which is used for data management, to assist the patient with allergies, and for the collection of scientific data. InterAll is cross-linked with the Allergome web platform from which it receives daily updates, and sends the data collected. InterAll is an essential tool for specialists because it facilitates the reading and evaluation of test results obtained by the multiplexed micro and nanotechnology test, and provides a tool for self-learning and continuous education. InterAll has been developed in six languages, English, French, German, Italian, Portuguese, and Spanish, and it automatically generates test reports in eight languages.
ADL, in tight collaboration with CAAM, has developed the "CAAM Digital Reporting System" (CDRS). CDRS is a dynamic tool to visualize the allergy test results. CDRS is an original and unique tool of its kind lacking anything similar released before. After registration and authentication in the CAAM web site reserved area, CDRS allows the patient to visualize the results of performed tests if integrated in the InterAll electronic record. The overall documentation and the comments related to each test result is not static as in a regular paper report or even in a pdf report, but is dynamic, because it is updated daily on the basis of data available or extracted from Allergome, InterAll, and ReTiME databases. CDRS is reachable by any mobile device or computer and represent a fundamental complement of the new FABER diagnostic test for allergy. The CDRS is available in 7 languages.
ADL is a Platinum Project Partners of the Allergome platform along with IBBR-CNR, MacroarrayDx, IFARAI and CAAM.
CAAM supports the scientific activities of the International Fund for Advanced Research in Allergy and Immunology (IFARAI Onlus). IFARAI Onlus is a non-profit organization that aims to support research in the field of allergic and immunologic diseases. The funds are collected annually for supporting young researchers and specific research projects. The project in the most advanced stage of development is AllergomeConsumer which sees the collaboration of IFARAI members as non-profit organization with the technical ADL help and the CAAM specialists. During the last few years IFARAI has been giving its support to research on identification and characterization of new allergenic molecules.
One of the sources of IFARAI Onlus fundraising is the annual donation of 5x1000 using the Italian tax code of IFARAI Onlus 91099790593. Any additional free donation is very welcome.
IFARAI is a Platinum Project Partner of the Allergome Platform along with ADL, IBBR-CNR and CAAM.
Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Austria.
The research center is directed by Prof. Rudolf Valenta. Historically it represents an international benchmark for molecular biology of allergens. In this research center pollen allergens from birch and grasses have been identified and cloned, and are now used in allergy diagnosis and in immunotherapy (vaccine) trials based on molecules rather than to the extracts.
In different laboratories of this research center genes encoding allergenic proteins are identified and then used for their production in the lab, and their following use, including the manipulation of the sequence/structure, to study the immune response and to establish new hypoallergenic products for future therapies.
CAAM specialists have a long lasting collaboration with the research center of Vienna, in particular with the leaders of specific research lines Dr. Susanne Vrtala, Dr. Birgit Linhart, and Dr. Margit Focke-Tejkl. Prof. Valenta is Chairperson of the Quality Assessment and Standardization Committee of the International Union of Immunological Societies, and a member of the Sub-Committee on Allergen Standardization of the International Union of Immunological Societies.
Department of Molecular Biology, University of Salzburg, Salzburg, Austria.
The research center is directed by Prof. Fatima Ferreira, currently Vice-Chancellor of the University of Salzburg, Austria. In the center has grown up a large group of bright young molecular biologists who have contributed to knowledge on allergens, performing studies on allergenic molecule structures and their function.
CAAM specialists collaborate with the research center of Salzburg since its inception, by identifying common field of interest in the characterization of new inhalant and food allergens. Leading researchers are Dr. Gabriele Gadermaier, Dr. Michael Wallner, Dr. Martin Himly. Prof. Ferreira is vice-chairperson of the Sub-Committee on Allergen Standardization of the International Union of Immunological Societies and member of the Allergen Nomenclature Sub-Committee of the International Union of Immunological Societies.
Department of Experimental Immunology, Academic Medical Center, Amsterdam, The Netherlands.
The research center is directed by Prof. Ronald van Ree, engaged in allergy research, for over twenty years, first at the Sanquin institute later on at AMC, mainly in the characterization of the allergens, in the epidemiology of allergic diseases, and in the creation of international standards for allergy. He was the organizer and coordinator of the International projects CREATE and FAST, financed by the European Union. CAAM specialists collaborate with the research center in Amsterdam as partner of International studies and clinical characterization of response to cross-reactive allergenic determinants. Prof. van Ree is a member of the Sub-Committee on Allergen Standardization of the International Union of Immunological Societies and of the Allergen Nomenclature Sub-Committee of the International Union of Immunological Societies.
Thanks to the collaborations of CAAM researchers, the identified allergens have been submitted to the most important database of protein sequences. UniProt is a consortium of prestigious International institutions. Allergome, the web platform dedicated to allergens, created, developed and constantly updated by CAAM researchers, is the only database for allergens cross-referenced in UniProt since 2011.
The allergenic protein sequences deposited in the UniProt database by CAAM researchers are: