“A truly unique heritage in knowledge and skills.”

Research in the field of allergy is our daily activity.

Sermolab S.r.l. The CAAM research and development lab is located at Sermolab S.r.l. There the experimental procedures are developed and tests are performed on new allergens and new diagnostic systems. All clinical activities performed in the CAAM healthcare network are addressed to the production of scientific data, to acquire new knowledge to be transferred in the routine care as quickly as possible.

Our main research interests are summarized below:

  • Identification and immunochemical characterization of high molecular weight allergens.
  • Molecular Biology of allergens.
  • Characterization and standardization of allergenic extracts.
  • Study of cross-reactivity among allergens and among haptens.
  • Creation and organization of computerized information systems in biomedicine.
  • Epidemiology of allergic diseases.
  • Development of new tools for diagnostic laboratory using micro and nanotechnology.
  • Qualitative evaluation of diagnostic tools in vivo and in vitro.
  • Clinical efficacy and safety of treatments with biologicals.
  • Clinical efficacy and safety of specific therapies (vaccines) and not.
  • Aerobiology of pollen and molecular allergens.
  • Identification and description of low molecular weight allergens.
  • Studies on adverse drug reactions having immunological mechanisms.
  • Studies of cellular immunity during hypersensitivity diseases.
  • Immunopathological mechanisms of Allergic syndromes.
  • Regulation of the IgE immunoglobulin class production and their characterization.

The major research projects:

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2011 -
INAIL – Dipartimento Medicina del Lavoro (ex ISPESL) - Risposta immunologica e rischio allergologico occupazionale da esposizione ad animali da laboratorio.
2009 - 2010
CRPA SpA - 2009 - P-R_NATURALMENTE FUNZIONALE - Individuazione di componenti e principi nutritivi a valenza funzionale presenti nel formaggio Parmigiano-Reggiano.
2009 -
AllergomeConsumer (www.allergomeconsumer.allergome.org).
2008 -
EU - FAST Project – Towards Safe and Effective Immunotherapy of Persistent Life-Threatening Food Allergies.
2000 -
Creazione, sviluppo e gestione della piattaforma web “Allergome – The Platform for Allergen Knowledge” (www.allergome.org).
2001 - 2005
EU - CREATE Project – Development of certified reference materials for allergenic products and validation of methods for their quantification.

Collaborations

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The CAAM has developed and maintained over the time stable partnerships with major research and development centers in Italy and abroad. In details with:

Istituto di Bioscienze e Biorisorse, Consiglio Nazionale delle Ricerche, Napoli. Institute of Bioscience and Bioresources, Consiglio Nazionale delle Ricerche, Naples, Italy.
The research laboratory is directed by Professor Maria Antonietta Ciardiello. It is one of the reference laboratories in Italy for the study on proteins.
In the laboratory all activities for protein extract preparations from tissues of various allergen sources are performed, as well as the identification and characterization of allergenic proteins including their sequencing, preparing them for subsequent use in diagnostics and for applications in the CAAM research laboratory.
The CAAM researchers are in close contact with leading researchers in the laboratory. Dr. Maurizio Tamburrini, Dr.ssa Lisa Tuppo, and Dr.ssa Ivana Giangrieco, work full-time on research and developments in the field of allergy.
IBBR-CNR is a Platinum Project Partner of the Allergome platform along with ADL, MacroarrayDx, IFARAI and CAAM.
IBBR-CNR is developing partner of the FABER diagnostic test for IgE detection in allergic diseases. In the IBBR-CNR lab exclusive allergenic molecules and verified allergenic extracts are produced, and the quality of materials obtained by other manufacturers is verified.

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Arbitrage Christian Harwanegg , one of the inventors of the first allergy test in microtechnology, the ISAC test, created MacroarrayDx in 2015. The idea is to generate new diagnostic systems upgrading the first generation microtechnology using the available nanotechnologies. Taking advantage of his huge expertise in the field, more than 15 years spent in bringing ISAC test from the 2002 experimental version to the current routine test, Dr. Harwanegg is now collaborating with CAAM and its partners and together they have released the FABER IgE allergy test.
In the FABER test development, MacroarrayDx is taking advantage of the collaboration and of the great technical expertise of Georg Mitterer, who has worked for 10 years to bring the ISAC test at its best performances, and now is fully engaged on the FABER development.
MacroarrayDx is a Platinum Project Partner of the Allergome platform along with IBBR-CNR, ADL, IFARAI and CAAM.

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Allergy Data Laboratories s.c. (ADL) CAAM maintains a privileged cooperation with the Allergy Data Laboratories s.c. (ADL), the company that has created and developed the Allergome website, maintaining it since 2003.

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Allergome
InterAll

Beyond the Allergome platform, ADL has developed the most important operational tool for the CAAM: the electronic medical record InterAll. This is the only example of a structured database for allergy specialists, which is used for data management, to assist the patient with allergies, and for the collection of scientific data. InterAll is cross-linked with the Allergome web platform from which it receives daily updates, and sends the data collected. InterAll is an essential tool for specialists because it facilitates the reading and evaluation of test results obtained by the multiplexed micro and nanotechnology test, and provides a tool for self-learning and continuous education. InterAll has been developed in six languages, English, French, German, Italian, Portuguese, and Spanish, and it automatically generates test reports in eight languages.

ADL, in tight collaboration with CAAM, has developed the "CAAM Digital Reporting System" (CDRS). CDRS is a dynamic tool to visualize the allergy test results. CDRS is an original and unique tool of its kind lacking anything similar released before. After registration and authentication in the CAAM web site reserved area, CDRS allows the patient to visualize the results of performed tests if integrated in the InterAll electronic record. The overall documentation and the comments related to each test result is not static as in a regular paper report or even in a pdf report, but is dynamic, because it is updated daily on the basis of data available or extracted from Allergome, InterAll, and ReTiME databases. CDRS is reachable by any mobile device or computer and represent a fundamental complement of the new FABER diagnostic test for allergy. The CDRS is available in 7 languages.

ADL is a Platinum Project Partners of the Allergome platform along with IBBR-CNR, MacroarrayDx, IFARAI and CAAM.


Ifarai
Allergome Consumer

CAAM supports the scientific activities of the International Fund for Advanced Research in Allergy and Immunology (IFARAI Onlus). IFARAI Onlus is a non-profit organization that aims to support research in the field of allergic and immunologic diseases. The funds are collected annually for supporting young researchers and specific research projects. The project in the most advanced stage of development is AllergomeConsumer which sees the collaboration of IFARAI members as non-profit organization with the technical ADL help and the CAAM specialists. During the last few years IFARAI has been giving its support to research on identification and characterization of new allergenic molecules.
One of the sources of IFARAI Onlus fundraising is the annual donation of 5x1000 using the Italian tax code of IFARAI Onlus 91099790593. Any additional free donation is very welcome.
IFARAI is a Platinum Project Partner of the Allergome Platform along with ADL, IBBR-CNR and CAAM.

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Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Austria. Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Austria.
The research center is directed by Prof. Rudolf Valenta. Historically it represents an international benchmark for molecular biology of allergens. In this research center pollen allergens from birch and grasses have been identified and cloned, and are now used in allergy diagnosis and in immunotherapy (vaccine) trials based on molecules rather than to the extracts.
In different laboratories of this research center genes encoding allergenic proteins are identified and then used for their production in the lab, and their following use, including the manipulation of the sequence/structure, to study the immune response and to establish new hypoallergenic products for future therapies.
CAAM specialists have a long lasting collaboration with the research center of Vienna, in particular with the leaders of specific research lines Dr. Susanne Vrtala, Dr. Birgit Linhart, and Dr. Margit Focke-Tejkl. Prof. Valenta is Chairperson of the Quality Assessment and Standardization Committee of the International Union of Immunological Societies, and a member of the Sub-Committee on Allergen Standardization of the International Union of Immunological Societies.

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Department of Molecular Biology, University of Salzburg, Salzburg, Austria. Department of Molecular Biology, University of Salzburg, Salzburg, Austria.
The research center is directed by Prof. Fatima Ferreira, currently Vice-Chancellor of the University of Salzburg, Austria. In the center has grown up a large group of bright young molecular biologists who have contributed to knowledge on allergens, performing studies on allergenic molecule structures and their function.
CAAM specialists collaborate with the research center of Salzburg since its inception, by identifying common field of interest in the characterization of new inhalant and food allergens. Leading researchers are Dr. Gabriele Gadermaier, Dr. Michael Wallner, Dr. Martin Himly. Prof. Ferreira is vice-chairperson of the Sub-Committee on Allergen Standardization of the International Union of Immunological Societies and member of the Allergen Nomenclature Sub-Committee of the International Union of Immunological Societies.


Department of Experimental Immunology, Academic Medical Center, Amsterdam, The Netherlands. Department of Experimental Immunology, Academic Medical Center, Amsterdam, The Netherlands.
The research center is directed by Prof. Ronald van Ree, engaged in allergy research, for over twenty years, first at the Sanquin institute later on at AMC, mainly in the characterization of the allergens, in the epidemiology of allergic diseases, and in the creation of international standards for allergy. He was the organizer and coordinator of the International projects CREATE and FAST, financed by the European Union. CAAM specialists collaborate with the research center in Amsterdam as partner of International studies and clinical characterization of response to cross-reactive allergenic determinants. Prof. van Ree is a member of the Sub-Committee on Allergen Standardization of the International Union of Immunological Societies and of the Allergen Nomenclature Sub-Committee of the International Union of Immunological Societies.


All National and International cooperation of the CAAM:

2014 -
Immunology, Asthma and Allergy Research Institute, Tehran, Iran (Prof. Zahra Pourpak); Dr. Raheleh Shokouhi Shoormasti, EAACI Fellowship 2014 Awardee;
2013 -
National Institute of Environmental Health Sciences (NIEHS), an institute of the National Institutes of Health, Durham, NC, USA (Dr. Geoffrey Mueller);
2013 -
Lung and Allergy Research Centre, School of Medicine, The University of Queensland, Australia (Dr. Janet Davis);
2012 -
Department of Toxicology and Risk Assessment, National Food Institute, Technical University of Denmark, Søborg, Denmark (Charlotte B. Madsen);
2012 -
Institute of Immunological Research, University of Cartagena, Cartagena, Colombia (Dr. Luis Caraballo);
2012 -
Division of Nutritional Sciences, School of Biosciences, University of Nottingham, Nottingham, UK (Dr. Marcos Alcocer);
2012 -
Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Children's Medical Center, Tehran, Iran (Prof. Pourpak and Prof. Moin);
2011 -
Dipartimento di Medicina del Lavoro, Settore Ricerca, INAIL, Roma, Italy (Dr. Maria Concetta D’Ovidio);
2011 -
Institut Pasteur, Département Infections & Epidémiologie, Paris, France (Dr. Pascal Poncet);
2011 -
Centre for Molecular Bioinformatics, Department of Biology, University of Rome Tor Vergata, Rome, Italy (Prof. Manuela Helmer-Citterich);
2011 -
Department of Immunotechnology, Lund University, Lund, Sweden (Prof. Mats Ohlin);
2010 -
Dipartimento di Biologia Applicata, University of Perugia, Perugia, Italy (Dr. Gianpiero Marconi);
2010 - 2012
Department of Organic and Industrial Chemistry, University of Parma, Parma, Italy (Prof. Arnaldo Dossena);
2009 -
Unit of Occupational Medicine, Department of Public Health and Community Medicine, University of Verona, Verona, Italy (Prof. Mario Olivieri);
2009 - 2010
Dipartimento di Farmacologia, Università di Milano, Italy (Prof. Patrizia Restani);
2008 -
Centre for Crop Genetic Improvement, Department of Plant Science, Rothamsted Research Harpenden, Herts, UK (Dr. Alison Lovegrove);
2008 -
Research Center Borstel - Division of Molecular and Clinical Allergology, Leibniz – Center for Medicine and Biosciences, Borstel, Germany (Prof. Uta Jappe, Dr. Arnd Petersen);
2008 -
Mount Sinai School of Medicine, New York (Prof. Xiu-Min Lin)
2008 -
University of Paranà, Cutiriba, Brazil (Prof. Nelson Rosario)
2008 -
Johns Hopkins University, Baltimore, USA (Prof. Robert Hamilton)
2008 - 2011
ALK-Abello China, Honk Kong, China (Prof. Michael Spangfort)
2008 -
Juntendo University, Tokyo, Japan (Prof. Hidenori Yokoi)
2008 -
Department of Medicine, Tulane University, New Orleans (Prof. Samuel B. Lehrer)
2008 -
University of São Paulo, Ribeirão Preto, Brazil (Prof. Karla Arruda)
2008 -
Laboratory of Immunogenetics and Allergology, CRP-Santé, Luxembourg (Prof. Annette Kuehn)
2008 -
Department of Immunology, Royal Free Hospital University College London, London, Great Britain (Prof. Bodo Grimbacher)
2008 -
Dipartimento di Agrobiologia ed Agrochimica. Università della Tuscia (Prof. Carla Caruso)
2007 - 2008
Department of Molecular and Cell Biology, Forestry and Forest Products Research Institute, Tsukuba, Japan (Dr. Norihiro Futamura)
2007 -
Food Allergy Research & Resource Program - University of Nebraska – Lincoln, NE, USA (Prof. Richard E. Goodman)
2007 -
Department of Pathophysiology, Center of Physiology and Pathophysiology, Medical University of Vienna, University of Vienna, Austria (Prof. Erika Jensen-Jarolim)
2007 - 2012
Centro di Allergologia – Complesso Integrato Columbus – Università Cattolica del Sacro Cuore – Rome, Italy (Prof. Antonino Romano)
2007 - 2009
Division of Allergology – Paul-Ehrlich-Institute – Langen – Germany (Prof. Stephan Scheurer)
2007 - 2009
Research and Development Department – Allergopharma – Reinbek – Germany (Dr. Andreas Braun)
2006 -
Allergens Department – Centro Nacional de Biopreparados, La Habana, Cuba (Dr. Alexis Labrada)
2006 -
Cellular Immunology Group - Institute for Research in Biomedicine, Switzerland (Dr. Federica Sallusto)
2006 -
Institute for Protein Biochemistry, Consiglio Nazionale delle Ricerche, Naples, Italy (Dr. Maria Antonietta Ciardiello)
2006 -
Department of Pharmacology, School of Pharmacy, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel (Prof. Francesca Levi-Schaffer)
2005 - 2011
Department of Pathophysiology, Center of Physiology and Pathophysiology, Medical University of Vienna, Austria (Prof. Barbara Bohle)
2005 - 2007
Research & Development Department Laboratorios Leti, Madrid, Spain (Dr. Enrique Fernandez-Caldas)
2005 - 2009
Research & Development Department – VBC-Genomics, Vienna, Austria (Dr. Christian Harwanegg)
2005 - 2007
Clinical Study Department – Ventria Bioscience, Sacramento, CA, USA (Prof. Delia R. Bethell)
2005 - 2009
Research & Development Department - Phadia, Uppsala, Sweden (Dr. Anders Sjolander)
2004 -
Research & Development Department – Siemens Healthcare Diagnostics, LA, USA (Dr. Debra Hovanec-Burns)
2004 - 2010
Biomedicine and Molecular Immunology Institute, Consiglio Nazionale delle Ricerche, Palermo, Italy (Dr. Paolo Colombo)
2004 -
USDA-ARS-SRRC, New Orleans, LA, USA (Prof. Soheila J. Maleki)
2003 - 2012
Institute of Immunology and Allergology, Inselspital, Bern, Switzerland (Prof. Beda Stadler)
2003 -
Institute of Pathophysiology, University of Vienna, Austria (Prof. Heimo Breiteneder)
2003 - 2009
Institute of Pathophysiology, University of Vienna, Austria (Prof. Karin Hoffman-Sommergruber)
2001 - 2005
Department of Biological Sciences, Functional Genomics Laboratories, University of Singapore, Singapore (Prof. Chew Fook Tim)
2001 - 2008
Institute of Genetics, University of Salzburg, Austria (Prof. Birgit Simon-Nobbe)
2001 -
Christian Doppler Laboratory for Allergy Diagnosis and Therapy Department of Molecular Biology, University of Salzburg, Austria (Prof. Fatima Ferreira)
2000 -
Department of Immunopathology, Academic University, Amsterdam, The Netherlands (Prof. Ronald van Ree)
2000 -
Christian Doppler Laboratory for Allergy Research, Division of Immunopathology, Department of Pathophysiology, Center of Physiology and Pathophysiology, Medical University of Vienna, Austria (Prof. Rudolf Valenta)
1984 - 2000
Laboratorio di Immunologia, Istituto Superiore di Sanità, Roma (Prof. Giuseppe Vicari e Dr. Carlo Pini)

Uniprot Thanks to the collaborations of CAAM researchers, the identified allergens have been submitted to the most important database of protein sequences. UniProt is a consortium of prestigious International institutions. Allergome, the web platform dedicated to allergens, created, developed and constantly updated by CAAM researchers, is the only database for allergens cross-referenced in UniProt since 2011.


Allergenic Sequences

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The allergenic protein sequences deposited in the UniProt database by CAAM researchers are:

1998 Jun o 4
Calcium-binding protein from Juniperus oxycedrus pollen (mediterranean juniper or coccolone juniper) – O64943
2004 Act c Chitinase_I
Endochitinases from Actinidia chinensis fruit (yellow kiwi) - P86473
2005 Art v 5
Polcalcin from Artemisia vulgaris pollen (Artemisia) - Q2KM81, A0PJ17
2006 Ara h 9
Lipid Transfer Protein from Arachis hypogea seeds (Peanuts) – B6CEX8, B6CG41
2008 Act c 5
Kiwellin from Actinidia chinensis fruit (yellow kiwi) - P85261
2008 Act d 5
Kiwellin from Actinidia deliciosa fruit (green kiwi) - P84527
2008 Act c 10
Lipid Transfer Protein from Actinidia chinensis fruit (yellow kiwi) - P85204
2008 Act d 10
Lipid Transfer Protein from Actinidia deliciosa fruit (green kiwi) - P85205, P85206
2006 Amb a 8
Profilin from Artemisia vulgaris pollen (Mugwort) - Q2KN23, Q2KN24
2006 Amb a 9
Polcalcin from Ambrosia artemisiifolia pollen (Ragweed ) - Q2KN26, Q2KN27
2006 Amb a 10
Polcalcin from Ambrosia artemisiifolia pollen (Ragweed ) - Q2KN25
2008 Car b 1
Bet v 1-like from Carpinus betulus pollen (hornbeam) - B6RQR6, B6RQR7, B6RQR8, B6RQR9, B6RQS0
2008 Que a 1
Bet v 1-like Quercus alba pollen (Oak) - B6RQS1, B6RQS2, B6RQS3
2008 Tri a 39
Serine Proteinase Inhibitor from Triticum aestivum seed (Wheat) - B3FHM6
2009 Cla h 9
Vacuolar serine protease Cladosporium herbarum spores (mould) - B7ZK61
2009 Cla h TCTP
Translationally Controlled Tumor Protein from Cladosporium herbarum spores (mould) - A1KXP4
2009 Art v 3
Lipid Transfer Protein from Artemisia vulgaris pollen (Mugwort) - C4MGH2, C4MGH1, C4MGH0, C4MGG9
2010 Mor n 3
Lipid Transfer Protein from Morus nigra fruit (Black mulberry) - P85894
2010 Ost c 1
Bet v 1-like from Ostrya carpinifolia pollen (hornbean) - E2GL17
2011 Api g 2
Lipid Transfer Protein from Apium graveolens stalks (Celery) - E6Y8S8
2011 Act d 11
RRP from Actinidia deliciosa fruit (green kiwi) - P85524
2011 Tri a 36
Low molecular weight glutenin from Triticum aestivum seeds (wheat) - B2Y2Q7
2012 Pru p 7
Anti-microbial peptide from Prunus persica fruit (Peach) - P86888
2012 Tri a 37
alpha-Purothionin from Triticum aestivum seeds (Wheat) - J7K291
2013 Pru p 7
Peamaclein from Prunus persica fruit (Peach) - P86888
2014 Sola l 6
7k-LTP from Solanum lycopersicum fruit (Tomato) - P86417
2016 Pun g 7
Pomaclein from Punica granatum fruit (Pomegranate) - C0HKC0
2017 Punein
Punein from Punica granatum - C0HKC6

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Centri Associati di Allergologia Molecolare - Studio Medico Associato
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